Recent studies have identified that late-onset invasive Staphylococcus aureus infections are a significant concern among infants admitted to neonatal intensive care units (NICUs). In particular, infants classified as having very low birth weight (VLBW), defined as weighing less than 1500 grams at birth, are at a notably higher risk for developing these infections compared to infants with greater birth weights. Staphylococcus aureus is a common bacterium that can cause severe infections, especially in individuals with weakened immune systems, such as premature or low birth weight infants. The data suggest that VLBW infants account for the majority of Staphylococcus aureus infections and related deaths in NICU settings. These findings highlight the importance of targeted infection prevention and control strategies in NICUs, especially for the most vulnerable infants. The research underscores the need for continued surveillance and intervention to reduce the incidence and impact of these infections among hospitalized neonates.