Ukraine conducted a drone attack in Russia that was reportedly planned over 18 months, coinciding with peace talks in Istanbul between Russian and Ukrainian delegates. The talks concluded quickly, with both sides agreeing to exchange wounded personnel.
A five-year analysis shows that a single administration of lifileucel, a tumor-infiltrating lymphocyte cell therapy, leads to durable responses and improved survival in patients with advanced melanoma who have already received prior treatment.
Recent Israeli airstrikes have hit school buildings in Gaza that were being used as shelters for displaced civilians. Reports suggest that more schools may be targeted following changes in operational controls on Israeli Defense Forces (IDF) actions at civilian sites.
South Korea is holding a snap presidential election following six months of political instability, which included a failed attempt to impose martial law and the impeachment of former president Yoon Suk Yeol. Key issues in the election include addressing the country's declining birth rate and ongoing political challenges.
Iran is reportedly close to rejecting a US proposal concerning its nuclear program, as the US draft requires Iran to suspend uranium enrichment within its territory and does not provide a clear path for lifting US economic sanctions.
A phase 3 randomized clinical trial has found that regular aerobic exercise can reduce the risk of colon cancer recurrence and death by 28%. The study suggests that any form of aerobic exercise may provide benefits comparable to certain chemotherapy treatments.
Astronomers have used the James Webb Space Telescope to identify water, carbon monoxide, and silicon monoxide in the dayside atmosphere of the exoplanet WASP-121b, and methane in its nightside atmosphere. This marks the first time silicon monoxide has been detected in an exoplanet's atmosphere.
Recent follow-up data from the CheckMate-77T trial indicate that perioperative nivolumab, combined with neoadjuvant chemotherapy and followed by adjuvant nivolumab, significantly prolongs event-free survival compared to placebo in patients with resectable non–small cell lung cancer (NSCLC). The benefit is particularly notable in patients who are ctDNA-negative or achieve a pathological complete response.
In the VERIFY clinical trial, the hepcidin mimetic rusfertide, when combined with standard care, showed significant improvements in clinical response rates and quality of life for patients with polycythemia vera compared to placebo.
The KEYNOTE-A18 study demonstrates that adding pembrolizumab to concurrent chemoradiotherapy leads to sustained survival improvements in patients with advanced cervical cancer, supporting its use as a standard of care.